Pippali (Long Pepper) 100 g, 50 g, 25 g

Pippali (Long Pepper)   100 g ($15.99), 50 g ($9.99), 25 g ($6.99)

Benefits:
Nutrients and Compounds
Indian long pepper, or pippali, is rich in alkaloids, beta sitosterol, and analgesic. It also has a ton of eugenol, glycosides, piperine, resins, sugar, saturated fat, essential oil, volatile oil, piplartine, myrcene, terpenoids, quercetin, triacontane, and sylvatine. These are all essential nutrients and compounds present in long pepper that contribute to the better functioning of your entire system.

It’s full of many good things that help our bodies work right. It has lots antioxidants – these are like little superheroes that go around cells, protecting them from damage and sickness. We get antioxidants from vitamins A, C and E, which pippali is overflowing with. It also contains important minerals like iron, calcium and zinc. We need these to make muscles strong, blood healthy, and brains smart.

Nutritive value in 100 grams of energy, moisture, protein, fat, carbohydrates, fibre, calcium, Iron and phosphorus.

Energy(Ecals)                                                                  310
Moisture(g)                                                                        12
Protein(g)                                                                             6
Fat(g)                                                                                     2
Mineral(g)                                                                            5
Fibre(g)                                                                                 8
Carbohydrates(g)                                                              66
Calcium(mg)                                                                  1230
Phosphorous(mg)                                                           190
Iron(mg)                                                                             62

Bioavailability Enhancer  Pippali improves the bioavailability of nutrients in food and herbal medicines. It is often used in Ayurvedic formulations to enhance the potency of other herbs. Piperine has been shown to enhance the bioavailability of structurally and therapeutically diverse drugs, possibly by modulating membrane dynamics, due to its easy partitioning and increasing permeability. The mechanism by which this compound enhances bioavailability is not understood. We hypothesize that this property may be attributed to increased absorption, which may be caused by altered membrane lipid dynamics and conformational change of enzymes in the intestine. Piperine also has been reported to enhance the oral bioavailability of phenytoin in humans [37, 38, 39].

Digestion  Imbued with excellent carminative and digestive properties, pippali even helps in treating a host of digestive woes. The potent anti-flatulent property reduces the formation of gas in the alimentary canal, thus reducing flatulence, bloating, constipation, and abdominal distension. Thanks to its powerful antacid property, the herb prevents the formation of excessive acids in the stomach thereby treating indigestion, ulcer, gastritis and promoting better absorption of nutrients in the body.

Stimulates digestive fire (Agni) to improve metabolism. Reduces bloating, indigestion, and gas, making food easier to digest. Helps in managing conditions like acidity, constipation, and sluggish digestion.

Diarrhea  Imbued with potent anti-bacterial and anti-diarrhoeal properties, pippali is extensively used for removing bacteria from the intestines that causes diarrhea and other intestinal infections. It holds a high significance in treating a type of diarrhea known as Ama Atisara i.e., acute diarrhea where the bowel is slimy, sticky, full of mucus and has a foul odour. The dried fruit powder not only removes the toxins from the body but also effectively reduces the frequency of stools.

Rejuvenates the Body & Enhances Longevity  Pippali is classified as a Rasayana (rejuvenator)in Ayurveda. Regular use supports overall vitality, strength, and longevity. It encourages selective apoptosis (cell death). It helps eliminate senescent (zombie) cells that increase in number as people age. These cells are closely connected with common signs of aging.

Senolytic herbs are natural compounds that help eliminate senescent cells, which are damaged cells that contribute to aging and inflammation. Some well-known senolytic herb compounds include quercetin, fisetin, and curcumin, which can support healthier aging by reducing inflammation and improving tissue. For more explanation about this, please see below.

Liver Protective  The plant fruit extract was assessed in rodents for its hepatoprotective action against carbon tetrachloride-induced acute, chronic reversible and irreversible damage using morphological, biochemical, and histopathological parameters. The extract stimulates regeneration by restricting fibrosis, but offers no protection against acute damage or against cirrhosis. Piperine was found to protect against tertiary butyl hydroperoxide-induced and carbon tetrachloride-induced hepatotoxicity by reducing lipid peroxidation in vitro and in vivo [25, 26].

The ethanol extract of the P. longum L. fruit yields piperlonguminine, piperine, and pipernonaline as the main antihyperlipidemic constituents. They exhibit appreciable antihyperlipidemic activity in vivo, which was comparable to that of the commercial antihyperlipidemic drug simvastatin [31].

Weight Loss  Pippali speeds up metabolism, promoting fat digestion and helps in managing Kapha-related weight gain and sluggishness.

Touted for its natural fat-burning properties, this aromatic spice effectively detoxifies the body by removing AMA toxins and reduces sudden hunger pangs and a craving for unhealthy foods. It improves digestion, reduces the accumulation of bad cholesterol in the body, thereby improving metabolism and helping the body to shed weight faster.

Pharmacological inhibition of acyl CoA diacylglycerol acyltransferase has emerged as a potential therapy for the treatment of obesity. Compounds containing piperidine groups are considered potential acyl CoA diacylglycerol acyltransferase inhibitors [41].

Heart  The effect of methanol extract of P. longum fruits was evaluated on adriamycin-induced cardiotoxicity (i.e., biochemical changes, tissue peroxidation damage, and abnormal antioxidant levels) in Wistar rats. Histopathological studies of the heart revealed degenerative changes and cellular infiltration in rats treated with adriamycin; however, pretreatment with P. longum reduced the intensity of these lesions. The results indicate that P. longum offers significant protection against adriamycin-induced oxidative stress and reduces cardiotoxicity by virtue of its antioxidant activity [44].

The amide dehydropipernonaline isolated from the fruit of P. longum L. has demonstrated the ability to induce coronary vasodilation [36].

Immune  The specific and nonspecific immunostimulatory actions of P. longum fruits have been evaluated by hemagglutination titer, macrophage migration index, and phagocytic index in mice. A well-known Ayurvedic preparation containing long pepper (pippali rasayana) was tested in mice infected with Giardia lamblia and found to activate macrophages, as shown by an increased macrophage migration index and phagocytic index, indicating immunostimulatory activity [28].

Analgesic (Pain Relieving)  The aqueous suspension of P. longum root powder (200, 400, and 800 mg/kg) was given orally to mice and rat to evaluate it analgesic effects. The delay in reaction time to thermal stimulus was assessed in rats, and the amount of writhing to chemical stimulus was assessed in mice. The effects of the 400 and 800 mg/kg doses of P. longum were similar to that of non-steroidal anti-inflammatory drugs (p<0.001). Both ibuprofen (40 mg/kg) and P. longum (800 mg/kg) demonstrated 50% protection against writhing. The delay in reaction time to thermal stimulus was <6% for different doses of P. longum as compared with 100% for pentazocine. This indicates that the plant root produces a weak opioid-type but potent non steroidal anti-inflammatory drug-type of analgesia [32].

Anti-Cancer  The alcohol extract of P. longum (10 mg/dose/animal) and piperine (1.14 mg/dose/animal) inhibits solid tumor development in mice induced with Dalton’s lymphoma ascites cells and increases the life span of mice. Piperine was also found to be cytotoxic (kills cancer cells) towards Dalton’s lymphoma ascites and Ehrlich ascites carcinoma cells at 250 μg/mL [22, 23].

Antioxidant  P. longum exhibits promising antioxidant potential against free radical-induced oxidative damage. Petroleum ether extract of the root and piperine from roots of P. longum Linn. decrease lipid peroxide levels and maintain glutathione content, demonstrating antioxidant activity [24].

Anti-Inflammatory  A marked anti-inflammatory activity of P. longum fruit decoction has been reported using carrageenan induced rat edema [19, 27].

Antimicrobial  Petroleum ether and ethyl acetate extracts of P. longum were found to exert antimicrobial effects against various microorganisms [29].

Diabetes  The exceptional hypoglycaemic property of pippali plays a significant role in assuaging the blood sugar levels of the body. The production of insulin from the β-pancreatic cells becomes active on taking pippali churna. It helps to reduce the breakdown of starch into glucose which in turn leads to low blood glucose levels.

Infections  Pippali is rich in antioxidants, helping the body fight infections and chronic illnesses. It strengthens the body’s natural defense system against seasonal colds and flu. The biochemical compounds present in this aromatic herb has been used since ancient times to shield the body against various infections. Thanks to its strong anti-viral, anti-bacterial, and antifungal properties, pippali is not only used for removing bacteria or germs from the body but also used for treating and healing wounds.

Menstrual  In the days leading up to the menstrual cycle, the hormones get haywire and can often lead to PMS symptoms like mood swings, stomach cramps etc. Pippali has been used since time immemorial for managing the heavy menstrual flow and combating menstrual cramps. Ancient healers used to give, pippali powder to induce contractions during delivery and even afterward to improve healing.

Respiratory  Pippali is an ultimate remedy for all sorts of Kapha aggravating disorders like asthma, bronchitis, COPD, cough and cold symptoms. It provides relief from cough and congestion and also helps in removing phlegm deposits from the respiratory tract. Pippali as a natural expectorant, loosening mucus and clearing nasal passages. It is beneficial for cough, cold, asthma, and bronchitis. Strengthens lung function and boosts oxygen circulation.

Mix 1 tsp of pippali powder, turmeric powder, dried ginger powder and 1 tsp of honey into a cup of lukewarm water. Take this herbal kadha to strengthen the lung tissues and improve lung health.

Libido  Boasted for being a natural aphrodisiac, pippali helps in reducing mental stress and anxiety and stimulates the hormones for increasing libido in both men and women. It also increases virility and stamina in men. Proper consumption on doctor’s recommendation promotes longevity and can also be used as an incredible remedy for erectile dysfunction.

Anti-Platelet  The inhibitory effects of the four acid amides piperine, pipernonaline, piperoctadecalidine, and piperlongumine, isolated from the fruits of P. longum L. were evaluated on washed rabbit platelet aggregation. All of the four tested acid amides dose-dependently inhibited washed platelet aggregation induced by collagen, arachidonic acid, and platelet-activating factor, but not that induced by thrombin [30].

Melanin-Inhibiting (Skin Lightening)  Piperlonguminine from P. longum inhibits melanin production in melanoma B16 cells stimulated with alpha-melanocyte-stimulating hormone, 3-isobutyl-1-methylxanthine, or protoporphyrin IX, where the compound exhibited stronger depigmenting efficacy. This effect was attributed to the inhibitory action of piperlonguminine on alpha-melanocyte-stimulating hormone signaling through cAMP to the cAMP-responsive element binding protein, which in turn regulates the expression of the microphthalmia-associated transcription factor, a key activator of tyrosinase expression. In this way the enzyme is inhibited internally, thereby suppressing the production of melanin [11].

Antidepressant  Ethanol extraction of P. longum fruits yields a known piperidine and piperine alkaloid, as a monoamine oxidase inhibitor. Thus the piper longum fruits represent a promising pharmacotherapeutic candidate against depression [34].

Radiation Protective  The radioprotective property of an ethanol extract of P. longum fruits was evaluated in Swiss mice. It reduced elevated levels of glutathione pyruvate transaminase, alkaline phosphatase, and lipid peroxidation in the liver and serum of radiation-treated animals. The extract also restored glutathione production to offer radioprotection [43].

Botanical Name: Piper longum
English: Long Pepper
Ayurvedic: Pippali, Maagadhi, Granthika, Pippalika, Maagadha, Maagadhaa, Maagadhikaa, Magadhodbhavaa. Vaidehi Upkulyaa, Pippalikam, Chapalaa, Kanaa, Krishnaa. Uushnaa, Shaundi, Kolaa, Tikshna-tandulaa
Unani: Filfil Daraaz. Daarfilfil
Also, known as: Long Pepper, Jaborandi, Dee Plee, Thippili, Arisi Thippili, Thippiliver, Bi Bo, Pipulmul, Piper Root, Gantoda, Ganthoda, Piparamula, Modikaddi, Hippali, Tippali, Modi, Kattuthippaliver, Tippaliveru, Pimplimula, Pippalimula, Bana Pippalimula, Pippalimula Magha, Kanda Tippili, Ambinadi Desavaram, Madikatta, Pipoli, Pipul, Pipil, Dulgiyat Piper, Bat But, Cheung Jiu, Chang Jiao, Langwerpige Peper, Balinese Pepper, Jaborandi Pepper, Bengal Pepper, Pikk Pipar, Pitkapippuri, Poivre Long, Langer Pfeffer, Stangenpfeffer, Balinesischer Pfeffer, Jaborandi-Pfeffer, Bengalischer Pfeffer, Makropipero, Pipari, Bali (Szigeti) Bors, Bengali Bors, Cabe Bali, Cabe Jawa, Lada Panjang, Pepe Lungo, Indonaga-Kosho, Hippali, Gajahippali, Morech Ansai, Pilbal, Bakek, Chabai Jawa, Kedawak, Pippla, Pimpli, Pipi, Pipla, Pipali, Piphli, Pieprz Długi, Magha, Darfilfil, Chanchala, Magandhi, Kana, Ushana, Tippili, Gajatippili, Podolgovati Poper, Langpeppar, Tippali, Vanapippili, Pippallu Kandandippili, Dok Dipli, Dipli, Dee Plee, Phrik-Hang, Dipli-Chueak, Pi-Pi Ling, Uzun Biber and Pipalli
Habitat: South Asian
Origin: India
Harvested: Wild or cultivated
Parts Used: The tiny berries, which merge to a single, rod-like structure.

General Information:
Piper longum is an underground creeper or under-shrub which has a large woody root and numerous creeping, jointed stems that are thickened at the nodes and grows in the sub-tropical climate of the Indian subcontinent. Herbal remedies have become popular, due in part to the lower risk of adverse reactions. Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine. The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine. Long pepper is a close relative of Piper nigrum, which gives black, green, and white pepper and has a similar but generally hotter flavor.

The leaves are alternate, ovate, spreading, without stipules and with blades varying greatly in size, 5.10 cm long, acuminate and have a cordate base. Flowers are unisexual, green or yellow with berries crowded in a black spike, 1 to 3 cm long and 1-3 mm in diameter When chewed it is greenish, slimy with a spicy odour and mild pungent smell, slightly different from that of black pepper Flowers grow in solitary spikes. The fruiting spike used as peepali is mainly obtained from various cultivars of P longum and allied species. The fruits, which grow in fleshy spikes 2-4 cm long and 3-4 mm thick, are oblong, blunt and blackish-green. The mature spikes are collected and dried as the commercial form of pippali, and the root radix is known as pippalimula. The root of Piper species, under the name peeplamul, is widely used in Ayurvedic medicines. The commercial drug consists almost entirely of transversely cut pieces, which are cylindrical, straight, or slightly curved some have distinct, swollen internodes exhibiting a number of leaf and rootlet scars. The surface is a dirty light brown. The drug has a peculiar odor and a pungent bitter taste that produces numbness on the tongue.

For over 2000 years, pippali was one of the most valuable Indian exports as both a food and a medicine. (Hippocrates considered it the latter rather than the former.) It’s mentioned in ancient Ayurvedic texts dating back 6000 years and has been included as an ingredient in hundreds of herbal remedies, most notably trikatu, a Sanskrit word meaning “three acrids,” trikatu is a mixture of black pepper, pippali, and ginger in equal proportion.

Traditionally, pippali was used for everything from leprosy and gonorrhea to paralysis of the tongue, evidently possessing “good anti-snake venom properties.” A modern pharmacologic analysis identified 20 drug-like phytochemicals in the spice, including the senolytic piperlongumine.

Most of the interest in piperlongumine to date has been in oncology after it was found to selectively kill off several different types of cancer, but that was in vitro, or in xenografts where, for example, piperlongumine treatment could shrink human breast cancer tumors implanted in mice by more than 50 percent within three weeks. No clinical cancer trials have been published to date, though.

Pippali has evidently been tested on patients with respiratory disorders and childhood asthma, reported to successfully decrease the severity of asthma attacks by more than 50 percent. This is not surprising given its anti-inflammatory properties that are as strong or stronger than anti-inflammatory prescription drugs in preclinical studies. Piperlongumine has been shown to improve cognitive function in aged mice, but its anti-aging potential has yet to be tested in people.

Piper longum is an underground creeper or under-shrub which has a large woody root and numerous creeping, jointed stems that are thickened at the nodes and grows in the sub-tropical climate of the Indian subcontinent. Herbal remedies have become popular, due in part to the lower risk of adverse reactions. Thousands of plants have been used traditionally to treat various diseases. Among them, species of the genus Piper are important medicinal plants used in various systems of medicine. The Piper longum fruit has been used in traditional medicine, including the Ayurvedic system of medicine. Long pepper is a close relative of Piper nigrum, which gives black, green, and white pepper and has a similar but generally hotter flavor.

 

How to use:
We make these suggestions to help you get the best benefit from the herbs that you’re choosing to improve your health. Also we make these ideas and recommendations so that consuming them easier and better fit into your lifestyle by adding them to the food that you already eat.
For the full health benefit, it is best to consume (or use the whole herb in poultices) the whole herb. All of the compounds in the herb act best together, as nature intends. Extracts draw out the most prominent beneficial compounds and may concentrate them. What is not extracted can be helpful in ways that we do not yet understand.

Cut Pieces or Powdered Herb:
There are different ways to use cut pieces or powdered herb.
Food Preparation: You can add powdered or pieces of herb (if the pieces you buy are bigger than you like, a coffee or herb grinder will quickly reduce) to any yogurt, smoothie, apple or other sauces, spreads, salads or other foods more familiar to you that don’t use heat. Heat can be damaging to the beneficial compounds in the herb. Other options like oatmeal, scrambled eggs, pasta sauce, soup, cookies and anything else that fits your lifestyle, but minimizing (by adding near the end of cooking) the heat is helpful.
Also, for children, you can mix powdered herb with honey or glycerin to make paste. The thicker the paste, the more potent and herbal in taste. The sweet taste of honey and glycerin will help medicine go down. The resulting liquid is called an electuary.
For seeds in general, but especially small seeds, it’s best to grind these to break the protective hulls a short time before consumption. This makes all the benefits available, rather than some remaining locked inside the hulls that are unbroken by insufficient chewing.
To make adding herbs even easier, you could add a week’s worth of your chosen herb(s) to an amount of, for example, yogurt that you would eat in a week. Mix thoroughly and eat this each day of the week. So you make once /week and just eat each other day.
Hot Infusion: The basic method for dried herbs and flower is, take 2-3 tablespoons of dried herb in a cup or teapot. Pour hot water over it and cover it with lid for 10-30 minutes. The heat from making tea can degrade some of the beneficial compounds in the herb. This method minimizes this effect. For the full health benefit, it is recommended to consume what is left over after making tea.
Decoctions: Decoctions are suitable for roots, barks, large seeds & berries, and other dense material. The simple way to make decoction is, in a saucepan, add 1 tablespoon of dried herbs to 1 cup of water, Bring the water to boil, reduce heat and simmer for 30-60 minutes with the pot covered. Squeeze out as much as liquid as possible. Best practice is to drink the liquid and also consume the solid material that remains. Herb pieces can also be used.
Powdered Herb:
There are different ways to use powdered herb.
Capsules: HerbsCrafters makes capsules guaranteed to be filled with the pure herb with no filler or any other products. You can also use powdered herb to make your own capsules at home. These capsules are best taken with liquid to aid in digestion and absorption and to ensure it doesn’t stick in your throat.
Poultice: Poultice can be made with an herbal powder and liquid (mostly water) to form a paste which is then applied to the skin. This method is very helpful for skin conditions.
Herbal shot: Powdered herb can be mixed with water, fruit juice or other liquid to make herbal shot.

Tips:
You can sweeten your herbal decoctions with bit of honey, natural fruit juice, stevia leaves powder or licorice root powder.

Precautions:
You should consult with a qualified healthcare practitioner before using any herbal products, particularly if you are pregnant, nursing, or on any medications.
All information on this website is for educational purpose ONLY.
This information has not been evaluated by Health Canada.
This information is not intended to diagnose, treat, cure, or prevent any disease.

How Much To Use
Recommended daily amount of pippali/long pepper powder is ¼–½ tsp (1–2 g)/use, up to 2 times/day. This can be, added to food, water, milk or a tbsp of honey.

 

Senolytic Action Herbs

As we get older, the number of aged, non-proliferating senescent cells that release a milieu of inflammatory molecules to surrounding cells increases throughout our bodies. The combination of molecules that senescent cells release (the senescence-associated secretory phenotype [SASP]) also induces healthy cells that come into contact with them to become senescent. Although many cells undergo programmed cell death (apoptosis), as we get older, more and more cells become senescent. Since our immunity wanes with age, our immune systems have a harder time disposing of senescent cells, also.

This age-associated accumulation of senescent cells causes tissue inflammation and organ damage. Intriguingly, some researchers propose age-related senescent cell accumulation is one of the reasons we age.

• Studies have shown eradicating senescent cells with senolytics improves tissue function.
• Researchers propose using senolytics may provide a means to counter age-associated organ deterioration.
• Supplementing mice with senolytics increases their median lifespans by as much as 25%.